verruciform xanthoma - HEALTHIES
Verruciform xanthoma is an uncommon, reactive, histiocytic lesion of oral cavity, first described in 1971 by Dr. Shafer Tuberous / tendinous xanthoma Yellow nodules on Achilles tendon and extensor tendons of fingers Large aggregates of foam cells throughout dermis Verruciform xanthoma Papillomatous, verruca-like change of overlying epidermis Verrucous architecture with hyperkeratosis, acanthosis and papillomatosis Focal parakeratosis, exocytosis of neutrophils ... Benign epithelial tumors & processes: frictional keratosis hereditary benign intraepithelial dyskeratosis (pending) multifocal epithelial hyperplasia pleomorphic adenoma pseudoepitheliomatous hyperplasia spongiotic gingival hyperplasia squamous papilloma verruca vulgaris verruciform xanthoma white sponge nevus O-Z: ossification pearly penile papules penile intraepithelial neoplasia (PeIN) Peyronie disease scrotal calcinosis squamous cell carcinoma-general squamous hyperplasia staging-male urethra staging-penis syphilis urethral carcinoma verruciform xanthoma WHO classification Penis & scrotum books Amin: 2022 Cheng: 2019 Verruciform xanthoma: May demonstrate similar clinical characteristics, although may have yellow hue Demonstrates foamy xanthoma cells within papillary projections Proliferative verrucous leukoplakia / verrucous leukoplakia: Characterized by multifocal white plaques with well defined margins Verruciform xanthoma: Similar clinically, although may have a yellow hue Demonstrates foamy xanthoma cells within papillary projections More likely to occur on gingiva (Head Neck Pathol 2019;13:80) Inward cupping of the rete pegs is not apparent Proliferative verrucous leukoplakia: May be confused with verruca vulgaris on small, incisional biopsies Answer D is incorrect because verruciform xanthoma is a rare mucocutaneous verrucopapillary lesion that is not associated with dyslipidemia.
Understanding the Context
Histopathology demonstrates epithelial hyperplasia with prominent parakeratinization. Skin inflammatory (nontumor) - Epidermodysplasia verruciformis 30 - 50% progress to invasive squamous cell carcinoma, mean age 31 years Equivocal cases are best distinguished by histology and viral testing, in context of clinical setting Flat, skin colored, red or hyperpigmented papules resembling flat warts or scaly brown pityriasis versicolor-like macules and patches Also seborrheic ...