Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a constellation of dermatological and osteoarticular symptoms. The pathogenesis of SAPHO is unknown, but infectious, genetic, immunological and environmental factors may play a role. SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes.

Understanding the Context

These diseases share some clinical, radiologic, and pathologic characteristics. SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO is an acronym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. SAPHO syndrome is classified along three different spectrums.

SAPHO syndrome causes, symptoms, diagnosis & treatment

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SAPHO syndrome causes, symptoms, diagnosis & treatment
Case Report: Concurrent SAPHO Syndrome and IgG4-RD
Mandibular Involvement in SAPHO Syndrome: A Single-center Retrospective
Mandibular Involvement in SAPHO Syndrome: A Single-center Retrospective
Mandibular Involvement in SAPHO Syndrome: A Single-center Retrospective
Clinical Manifestations and Management of US Patients with SAPHO
SAPHO syndrome and medication recommendations | JIR
SAPHO syndrome and medication recommendations | JIR
SAPHO syndrome and medication recommendations | JIR
Coexistence of adult-onset Still’s disease and SAPHO syndrome
Is palmoplantar pustulosis combined with hip involvement a SAPHO syndrome?
Factors Associated with Health-related Quality of Life in Adults with
Awareness of the Risk of Paradoxical Psoriasis in Patients with SAPHO | JIR
Síndrome De Sapho Tem Cura - RETOEDU
Hablemos sobre el Síndrome de Sapho. El Síndrome de Sapho es una
Evaluating Cellulitis and Possible Osteomyelitis in the Setting of
Evaluating Cellulitis and Possible Osteomyelitis in the Setting of
SAPHO syndrome | Eurorad
SAPHO syndrome | Eurorad
SAPHO Syndrome - The American Journal of the Medical Sciences
SAPHO syndrome with mandibular manifestation | BMJ Case Reports
A Case of SAPHO Syndrome Presenting as Isolated Iliitis and Spondylitis
SAPHO syndrome | Eurorad
Is SAPHO Syndrome Linked to PASH Syndrome and Hidradenitis Suppurativa
Copy Number Variation of Multiple Genes in SAPHO Syndrome | The Journal
Mandibular involvement in SAPHO syndrome: a retrospective study - PMC
Astonishing improvement of destructive mandibular osteomyelitis by
Whole-spine Computed Tomography Findings in SAPHO Syndrome | The
A case of bronchiolitis obliterans organising pneumonia associated with
Carotid Ulceration in a Young Woman with SAPHO Syndrome - European

Key Insights

Imperfect forms of these. Prevalence of CRMO is estimated at 0.04% whilst the other entities are rarer. How is the diagnosis made? SAPHO syndrome is suspected when a patient presents with a pustular skin disease in association with rheumatic pain. SAPHO syndrome encompasses a wide spectrum of anomalies characterized by variable combinations of osteoarticular and cutaneous manifestations of varying degrees of severity.

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Final Thoughts

The onset of bone and joint pain, stiffness and swelling is most often insidious. SAPHO syndrome involves any combination of: Synovitis (inflammation of the joints), Acne, Pustulosis (thick yellow blisters containing pus) often on the palms and soles, Hyperostosis (increase in bone substance) and Osteitis (inflammation of the bones). SAPHO syndrome | About the Disease | GARD - Genetic and Rare Diseases ... SAPHO syndrome is rare, with a reported frequency of 1 in 10,000 in the Caucasian population. However, the actual incidence of SAPHO syndrome is unknown, and the incidence of the disease is likely higher. The pathogenesis of SAPHO syndrome remains incompletely understood.

Keep reading to learn more about SAPHO syndrome, including its symptoms and treatment. We also discuss the outlook for people with this disease. Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare, underdiagnosed disease with a wide clinical spectrum. Current and future advances in practice: SAPHO syndrome and chronic non ...