neutrophilic dermatosis - HEALTHIES
What are neutrophilic dermatoses? Neutrophilic dermatoses are autoinflammatory skin conditions characterised by dense infiltration of inflammatory cells (neutrophils) in the affected tissue. They arise in reaction to some underlying systemic illness.
Understanding the Context
A neutrophilic dermatosis may be seen in isolation or more than one type may occur in the same individual. Neutrophilic dermatoses often arise at ... Acute febrile neutrophilic dermatosis is a rare skin condition characterised by a sudden onset of painful, inflamed skin lesions associated with fever. Acute febrile neutrophilic dermatosis also has the eponymous name, Sweet syndrome, named after Dr Robert Douglas Sweet from Plymouth, England, who first described it in 1964.
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Key Insights
Created 2008. Learning objectives Recognise neutrophilic dermatoses Introduction Dermatoses with dense dermal infiltrates of neutrophils include: Acute febrile neutrophilic dermatosis Pyoderma gangrenosum (PG) Overlap disorders Neutrophilic dermatoses are probably mediated through helper T cell type 1 cytokines (IL-2, INF-ฮณ) rather than helper T cell type 2 cytokines (IL-4). This results in ... Neutrophilic dermatosis of the hands may be the presenting sign of a serious blood condition. A full blood count may reveal raised or reduced numbers of red cells, white cells and/or platelets.
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Further investigation may require bone marrow examination. What is the outcome of neutrophilic dermatosis of the hands? View pictures of acute febrile neutrophilic dermatosis (Sweet syndrome) in the gallery below. Acute febrile neutrophilic dermatosis is an uncommon skin condition characterised by fever and inflamed or blistered skin and mucosal lesions. Neutrophilic dermatoses are autoinflammatory conditions often associated with systemic disease. What is IgA pemphigus?
IgA pemphigus (or immunoglobulin A pemphigus) is an autoimmune blistering disorder. It is also called intercellular IgA dermatosis among other names. IgA pemphigus has two major subtypes: Subcorneal pustular dermatosis (SPD) type Deposition of intracellular IgA against the glycoprotein desmocollin-1 seen predominantly in the upper epidermis. Intraepidermal neutrophilic ...