Monthly Prescribing Reference: Reltecimod Under Review for Organ Dysfunction/Failure With Necrotizing Soft Tissue Infection What turns a relatively minor skin injury into the life-threatening horror show? That would be necrotizing soft tissue infection, otherwise known as a flesh-eating bacterial infection. New research ...

Understanding the Context

A necrotizing soft tissue infection can destroy skin, muscle, and other soft tissues. If untreated, it may lead to amputation of major parts of the body, kidney failure and a high risk of death. Necrotizing soft tissue infections represent a spectrum of diseases characterized by extensive necrosis involving the skin, subcutaneous tissues, fascia or muscles. These infections are generally severe and rapidly progressive, often accompanied by ...

Key Insights

In this review, we describe the clinical and laboratory features of necrotizing fasciitis and other necrotizing soft-tissue infections. We also discuss diagnostic pitfalls and recommended... Necrotizing soft tissue infection develops when the bacteria enters the body, usually through a minor cut or scrape. The bacteria begin to grow and release harmful substances (toxins) that kill tissue and affect blood flow to the area. Importance Necrotizing soft tissue infections (NSTIs) are severe life- and limb-threatening infections with high rates of morbidity and mortality.

Final Thoughts

Unfortunately, there has been minimal improvement in outcomes over time. Necrotizing soft-tissue infections (NSTIs) are acute, rapidly progressive infections of soft tissues, often associated with signs of severe systemic toxicity and progressive multi-organ failure. Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections characterized by an extensive necrosis of skin and subcutaneous tissues. ABSTRACT: Necrotizing soft tissue infections are rare bacterial infections of the skin and soft tissues with a high morbidity and mortality rate, requiring prompt diagnosis and surgical intervention. Medscape: Increased Risk for MRSA Skin and Soft Tissue Infections Among HIV-Infected Persons Increased Risk for MRSA Skin and Soft Tissue Infections Among HIV-Infected Persons After a natural disaster, physicians should be aware that fungi can cause those injured in the incident to develop soft tissue infections, which are most likely to occur if the injured party sustains ... The incidence of necrotising soft-tissue infections has increased during recent decades such that most physicians might see at least one case of these potentially life-threatening infections in their career.