Focal cutaneous mucinosis (see the pathology of focal cutaneous mucinosis): a harmless solitary lesion less than 1 cm in diameter that can be removed by surgical excision if required. The pathogenesis of focal mucinosis is similar to that of myxoid cysts of the fingers and toes, and minor variations may be related to the anatomical differences of the involved sites. Similarities to and differences from other cutaneous mucinoses and myxomas are discussed.

Understanding the Context

We describe the dermoscopy of two cases of cutaneous focal mucinosis. Both lesions presented a nonspecific homogenous whitish pattern; the first case also exhibited a sharply demarcated yellow border. Solitary cutaneous focal mucinosis is a unique condition defined by the presence of mucin, a hyaluronic acid complex, in the dermis. The lesion typically presents as an isolated, asymptomatic papule or nodule on the extremities or back and is not associated with any systemic condition.

Key Insights

Cutaneous focal mucinosis is a "pseudotumorous" skin disease characterized by the presence of localized, non-encapsulated deposits of proteoglycans (mucins) in the dermis. Lesions of focal mucinosis present with a dome-shaped elevation of the skin and a circumscribed dermal pool of mucin (figures 1, 2). Involvement of the subcutaneous tissue is uncommon. Cutaneous focal mucinosis: an asymptomatic, solitary, skin‐coloured papule or nodule, sometimes with a cystic appearance, that can occur anywhere on the body but not in proximity to the joints of the hands, wrists or feet Follicular Mucinosis: Follicular mucinosis is a type of mucinosis that affects the hair follicles, leading to hair loss and the formation of follicular papules or plaques on the skin. Mucinosis is a rare condition characterized by the accumulation of mucin in the skin.

Final Thoughts