Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed and potentially fatal disease of the heart muscle. As it progresses, the heart can become unable to adequately squeeze to pump blood out of the heart, ultimately leading to heart failure. Transthyretin amyloidosis (ATTR) happens when clumps of irregular proteins build up in tissues like your heart and nerves.

Understanding the Context

It can affect other parts of your body, too, like your kidneys and eyes. ATTR amyloidosis is related to the abnormal production and buildup of a type of amyloid called transthyretin. Learn about symptoms, diagnosis, and treatments. Learn how transthyretin amyloid cardiomyopathy (ATTR-CM) affects the heart and body, warning signs, and FDA-approved treatments that improve quality of life.

Key Insights

ATTR-CM symptoms can be mistaken for other heart problems or types of amyloidosis, which makes diagnosis tricky. But doctors have several ways to figure out if you have it. ATTR-CM is a heart condition caused by abnormally shaped protein deposits. Learn the causes, symptoms, treatments, and other facts and tips for living with this heart condition. ATTR amyloidosis is a progressive disease.

Final Thoughts

Learn about the three stages of the disease and how its progression affects treatment. What is ATTR-CM? ATTR-CM (transthyretin cardiac amyloidosis) is a disease caused by the buildup of abnormal protein deposits, called amyloid. In ATTR-CM, a protein called transthyretin (TTR), which normally circulates in the bloodstream, becomes misshapen and builds up in the heart, nerves, and other organs.