actinomyces - HEALTHIES
Actinomycosis in human is most commonly caused by Actinomyces israelii [1,3,21–26] which is an endogenous commensal present in the oral and GI-tract flora. [9,10,12,22,27] Actinomycetes typically ... Actinomyces and CCL11 are identified as significant contributors to idiopathic pulmonary fibrosis through the gut-lung axis.
Understanding the Context
Mendelian randomization implicated 12 gut microbiota taxa and 8 ... The New England Journal of Medicine: Actinomyces Hepatic Abscess with Cutaneous Fistula Cultures of a specimen obtained by fine-needle aspiration of a liver lesion showed only Actinomyces israelii (inset). The patient was started on intravenous ampicillin and sulbactam. After eight weeks ...
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Actinomycosis is an infection with Actinomyces bacteria. It causes pus-filled wounds, usually around your face and mouth, which spread to nearby tissue. Actinomyces species are ubiquitous, occurring in soil and in the microbiota of animals, including the human microbiota. They are known for the important role they play in soil ecology; they produce a number of enzymes that help degrade organic plant material, lignin, and chitin. Actinomycosis is a rare chronic disease caused by Actinomyces spp., anaerobic Gram-positive bacteria that normally colonize the human mouth and digestive and genital tracts.
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The causative organisms, Actinomyces species (most commonly A. israelii), are often present commensally on the gums, tonsils, and teeth and may be present in the intestines and vagina. Actinomyces bacteria are anaerobes and do not require oxygen to live. Actinomyces bacteria cause infection only when the surface of the tissue on which they reside is broken, enabling them to enter other, deeper tissues, which have no defenses against them. Actinomyces spp. reside on mucosal surfaces and gain access to deeper tissues via surgical procedures, trauma, etc., disrupting the mucosal barrier.
The main niche is the oral cavity/pharynx. Actinomyces spp. are a group of bacteria commonly found within the human body. Though often harmless, these microorganisms can sometimes lead to a chronic infection known as actinomycosis.