trousseau's syndrome - HEALTHIES
Trousseau's syndrome, also known as thrombophlebitis migrans or migratory superficial thrombophlebitis, is a rare but significant paraneoplastic manifestation associated with various cancers. The Trousseau sign of malignancy or Trousseau's syndrome is a medical sign involving episodes of vessel inflammation due to blood clot (thrombophlebitis) which are recurrent or appearing in different locations over time (thrombophlebitis migrans or migratory thrombophlebitis). Trousseau syndrome is an acquired blood clotting disorder that results in migratory thrombophlebitis (inflammation of a vein due to a blood clot) in association with an often undiagnosed malignancy.
Understanding the Context
The syndrome of migratory thrombophlebitis as a sign of malignancy bears the name of Ar-mand Trousseau, who in 1865 published the fi rst clinical record associating undiagnosed visceral malignancy and unexpected throm-bosis. s syndrome and Trousseau syndrome yields mostly nonoverlapping hits. Such searches, along with review of web-based sources, yield definitions of Trousseau’s syndrome ranging from “occurrence of thrombophlebitis migrans with vis-ceral cancer” and, “spontaneous recurrent or migratory venous thromboses and/or arterial emboli caused by ... Trousseau syndrome was first described by Armand Trousseau in 1865 as an unexpected or migratory thrombophlebitis (inflammation in the vein related to a blood clot) forewarning a malignancy.
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Key Insights
Trousseau's syndrome (cancer-associated thrombosis) is the second leading cause of death in cancer patients, after death from cancer itself. The risk of a venous thromboembolism is 4- to 7-fold higher in patients with cancer than in those without cancer. Trousseau syndrome is a hypercoagulative state that can result in various thromboembolic events, including multiple brain infarctions, often associated with underlying malignancy.