Yahoo: Parry-Romberg Syndrome (PRS), a rare autoimmune disorder that gradually destroys soft tissue on one side of the face. At age 7, Lukas Caldwell developed a faint discoloration on his face and was diagnosed with Parry-Romberg Syndrome, a rare disorder that gradually destroys facial tissue He underwent multiple ... Parry-Romberg Syndrome (PRS), a rare autoimmune disorder that gradually destroys soft tissue on one side of the face.

Understanding the Context

Parry–Romberg syndrome (PRS) is a rare disease presenting in early childhood [1] characterized by progressive shrinkage and degeneration of the tissues beneath the skin, usually on only one side of the face (hemifacial atrophy) but occasionally extending to other parts of the body. [2] Parry-Romberg syndrome, also known as Romberg’s disease or progressive hemifacial atrophy, is a rare atrophic disorder characterized by a progressive deterioration of the skin and soft tissues of half the face. Parry-Romberg syndrome is a rare, acquired disorder characterized by slowly progressive shrinkage (atrophy) of the skin and soft tissues of half of the face (hemifacial atrophy). We present 7 cases of Parry Romberg syndrome and their associated clinical and imaging findings with specific attention to the radiographic characteristics of this disease.

Key Insights

What is Parry-Romberg syndrome? Parry-Romberg syndrome (PRS) is a rare acquired disorder characterised by the progressive atrophy of skin, fat, muscle, bone, and cartilage typically on one side of the face. Systemic manifestations may occur, particularly with neurologic and ophthalmic involvement. What is Parry-Romberg syndrome? Read on to learn more about this condition, including possible symptoms, potential causes, and if it impacts life expectancy.

Final Thoughts

Parry-Romberg syndrome (PRS) is a rare neurocutaneous and craniofacial disorder characterized by progressive hemifacial wasting and atrophy that predominantly affects children and young adults, with an estimated prevalence of 1 in 700,000 individuals. Parry-Romberg syndrome (PRS) is a rare disorder characterized by slowly progressive hemifacial atrophy affecting facial subcutaneous tissue, muscle, cartilage, and bone. This disease was first described in 1825 by Dr. Caleb Hillier Parry in a collection of his medical writings. It was described a second time in 1846 by Dr. Moritz Heinrich Romberg, thus the name Parry Romberg.

This page from Great Ormond Street Hospital (GOSH) explains the causes, symptoms and treatment of Parry-Romburg syndrome. The condition usually starts in childhood when the skin and soft tissues start to waste away (atrophy).