giant cell fibroma - HEALTHIES
Oral cavity & oropharynx - Giant cell fibroma, benign fibrous proliferation of the oral cavity with distinct stellate fibroblasts Central odontogenic fibroma associated with central giant cell granuloma (CGCG) In some cases, the COF and CGCG histologic components were not intimately admixed; rather, they were arranged in a juxtaposed yet separate dimorphic pattern In other cases, the two patterns comingle (see Fig. 7 below, Head Neck Pathol 2017 Aug 7 [Epub ahead of print]) Peripheral ossifying fibroma (POF) is a benign, reactive lesion that most commonly arises on the gingiva. Characterised by a fibrocellular proliferation with variable deposition of calcified material ...
Understanding the Context
Peripheral ossifying fibroma is a reactive gingival proliferation characterized by spindle cell proliferation with calcification or ossification The lesion is a tenosynovial giant cell tumor, localized type (also called giant cell tumor of tendon sheath). Although all the listed cell types can be seen in varying proportions within the tumor, the histiocytoid mononuclear cells are the neoplastic component and should always be present. Giant cell fibroblastoma is a locally aggressive subcutaneous fibroblastic neoplasm, arising predominantly in pediatric population Peripheral giant cell granuloma is a benign, likely reactive, gingival mass that clinically resembles a pyogenic granuloma and is characterized histopathologically by a proliferation of mononuclear cells and multinucleated giant cells. F-N: fibrous dysplasia ghost cell odontogenic carcinoma gingival cyst (adult) gingival cyst (newborn) glandular odontogenic cyst grossing (pending) inflammatory collateral cyst juvenile trabecular ossifying fibroma and psammomatoid ossifying fibroma Langerhans cell histiocytosis lateral periodontal cyst and botryoid odontogenic cyst lymphoma ...
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Key Insights
Giant cell tumor of bone, NOS (GCTB) is a locally aggressive and rarely metastasizing neoplasm composed of neoplastic mononuclear stromal cells admixed with macrophages and osteoclast-like giant cells Central giant cell granuloma is a benign, nonodontogenic lesion of the jaw, osteoclastic in origin, with unknown etiology that can be locally aggressive and destructive.