epithelioid cell histiocytoma - HEALTHIES
In epithelioid histiocytoma, sections show a centrally located, circumscribed tumour underlying an epidermal collarette (figure 1). The tumour is composed of epithelioid cells arranged in sheets and sometimes a storiform pattern. Results: Epithelioid cell histiocytoma is characterized by proliferation of angulated epithelioid cells with abundant eosinophilic cytoplasm.
Understanding the Context
Immunostaining for S-100 protein and HMB-45 were negative. The majority of cells had positive reactions to staining for vimentin and α1 -antitrypsin. Epithelioid benign fibrous histiocytoma, also known as ‘epithelioid cell histiocytoma,‘ has traditionally been considered a morphologic variant of cutaneous fibrous histiocytoma with prominent epithelioid cytomorphology. Epithelioid cell histiocytoma (ECH) is a benign tumor of the dermis which can closely resemble other benign and malignant tumors showing epithelioid features.
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Key Insights
Correct diagnosis is needed to prevent unnecessary treatment. Epithelioid Cell Histiocytoma: a Case Report and Brief Review of the ... Epithelioid fibrous histiocytoma (EFH) is a benign fibrohistiocytic neoplasm characterized by morphologic heterogeneity and recurrent anaplastic lymphoma kinase (ALK) gene rearrangements. Explore epithelioid fibrous histiocytoma. Get clear insights into this rare, benign skin growth, from its nature to clinical management.
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In view of the tremendous potential for overlap among ALK fusion partners, the purpose of this study was to interrogate a large cohort of cases of epithelioid fibrous histiocytoma to characterize the nature and prevalence of ALK products in this neoplasm. Explore the morphology, diagnosis, and clinical progression of epithelioid fibrous histiocytoma, including its typical presentation and ALK protein involvement. Epithelioid fibrous histiocytoma (EFH) is a type of uncommon skin tumor mostly harboring Anaplastic Lymphoma Kinase (ALK) gene rearrangement, with different fusion partners reported.