Angiokeratomas are benign, red-blue wart-like skin lesions that are more common in older individuals. They are classified according to body site, and some types have a male or female predominance. Introduction Angiokeratoma presents as a blood-filled papule which may bleed following trauma.

Understanding the Context

There are a range of clinical presentations ranging from isolated lesions of little consequence to widespread lesions associated with Fabry disease. Histology of angiokeratoma In angiokeratoma, the histopathology shows a vascular lesion in the superficial dermis which extends into the epidermis ... Fabry disease is a rare inherited lysosomal storage disorder [1]. It is also known as Anderson–Fabry disease and angiokeratoma corporis diffusum.

Key Insights

Fabry disease causes clusters of angiokeratomas (small, dark red spots on the skin) and many systemic symptoms due to the deposition of globotriaosylceramide (Gb3) in multiple organs. View pictures of angiokeratoma in the gallery below. An angiokeratoma is a benign capillary ectasia in the superficial dermis that presents as an asymptomatic blue-red hyperkeratotic papule anywhere on the skin. Angiokeratoma presents as a blood-filled papule which may bleed following trauma. There are a range of clinical presentations ranging from isolated lesions of little consequence to widespread lesions associated with Fabry disease.

Final Thoughts

Angiokeratoma: acquired scaly angiomas, usually on vulva or scrotum, or in association with Fabry disease Glomus tumour: tender papule on nail bed or palm arising in young to middle-aged adult Pyogenic granuloma occurs in children and young adults on skin and mucosa, most often lower lips, fingers and toes.