amyloidosis nails - HEALTHIES
Not everyone with systemic amyloidosis or going through chemotherapy will have changes in their nails, but it’s something to be aware of. Here are some nail changes you may experience. People with amyloid light-chain amyloidosis (AL amyloidosis), the most common type, are the most likely to have nail and skin changes.
Understanding the Context
Amyloidosis can cause several changes to the fingernails, including: Systemic amyloidosis results from the abnormal extracellular deposition of amyloid protein. Different types of systemic amyloidosis vary on the basis of the amyloidogenic precursor protein. Our case demonstrated biopsy-proven early nail involvement in AL amyloidosis, highlighting the fact that nail changes can be the first manifestation of systemic amyloidosis, and dermatologists can aid in early diagnosis (4,5). Nail abnormalities in systemic amyloidosis AL are rarely described.
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Key Insights
They can take many forms and can sometimes be the only cutaneous manifestation of systemic amyloidosis. Amyloidosis is a systemic disease with multiple clinical manifestations because of the deposit of amyloid substance in many tissues and, in rare cases, nail involvement can be the unique... In summary, this case presents a rare cutaneous presentation of systemic AL amyloidosis, which includes extensive hair loss and nail changes. Eventually, evaluation of nephrotic range proteinuria revealed monoclonal lambda free light chains, and AL amyloidosis was confirmed by bone marrow biopsy. An unusual case of AL amyloidosis presenting as alopecia and nail ...